1. Signaling Pathways
  2. PROTAC
  3. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (330):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138679
    Aberrant tau ligand 2 2417159-58-9
    Aberrant tau ligand 2 (Compound 4-12) is the ligand for tau protein and can be used as target protein ligand for synthesis of PROTAC degrader C004019 (HY-138669).
    Aberrant tau ligand 2
  • HY-170856
    RET ligand-4
    RET ligand-4 is the target protein ligand of YW-N-7 (TFA) (HY-170855A). YW-N-7 (TFA) is a PROTAC targeting RET kinase, which can be used for research in the field of cancer.
    RET ligand-4
  • HY-176044
    PCSK9 ligand 2 3039841-82-9
    PCSK9 ligand 2 is a target protein ligand for PROTAC PCSK9 autophagic degrader 2 (HY-176043), which can be used in antiatherosclerosis research.
    PCSK9 ligand 2
  • HY-176529
    ERK5 ligand-1 2919963-36-1
    ERK5 ligand-1 is a is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). ERK5 ligand-1 can be used to design PROTAC, such as PROTAC ERK5 degrader-1 (HY-176528).
    ERK5 ligand-1
  • HY-172954
    Androgen receptor ligand 1 3077430-87-3
    Androgen receptor ligand 1 is an androgen receptor (AR) ligand. Androgen receptor ligand 1 binds to CRBN E3 ligase via a linker to form an AR PROTAC degrader. Androgen receptor ligand 1 can be used in the study of prostate cancer.
    Androgen receptor ligand 1
  • HY-135832
    Demethyl-RSL3 2375354-13-3
    Demethyl-RSL3 is a ligand for target protein for pROTAC.
    Demethyl-RSL3
  • HY-162841
    HPK1 ligand 1
    HPK1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). HPK1 ligand 1 can be used for synthesis PROTAC PD-L1 degrader-2 (HY-162816).
    HPK1 ligand 1
  • HY-151479
    GID4 Ligand 3 340007-39-8
    GID4 Ligand 3 (compound 16) is a binder of GID4 with an Kd value of 110 μM in vitro and an IC50 value of 148.5 μM. GID4 Ligand 3 can be used for the research related to cereblon and Von Hippel-Lindau.
    GID4 Ligand 3
  • HY-176124
    CDK2 ligand-2 3030281-30-9
    CDK2 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). CDK2 ligand-2 combined with E3 Ligase Ligand-linker Conjugate 184 (HY-176125) can be used to synthesize PROTAC degrader (CDK2 degrader 2 (HY-163815)).
    CDK2 ligand-2
  • HY-168195
    DYR530 2410298-39-2
    DYR530 is a ligand for target protein (protein kinases DYRK1A) for PROTAC (HY-168194).
    DYR530
  • HY-169439
    Temozolomide-amino hydrochloride 449187-98-8
    Temozolomide-amino hydrochloride (compound 8) is an activity control for the target protein ligand of Naph-Se-TMZ (HY-169433).
    Temozolomide-amino hydrochloride
  • HY-172360
    HDAC6 ligand-3
    HDAC6 ligand-3 is a ligand for HDAC6 that can be used as target protein ligand for synthesis of PROTAC HDAC6 degrader 4 (HY-172359).
    HDAC6 ligand-3
  • HY-172624
    AR antagonist 14 2757424-54-5
    AR antagonist 14 is is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). AR antagonist 14 can be combined with VH 101-amide-piperidine-Pip-alkyne (HY-172625) to synthesize PROTAC degraders (ARD-69 (HY-114402)).
    AR antagonist 14
  • HY-169374
    Naproxen Gilteritinib 1373410-40-2
    Naproxen Gilteritinib is the active reference substance of Gilteritinib (HY-12432). Gilteritinib is the target protein ligand of PROTAC degrader LWY713 (HY-157213).
    Naproxen Gilteritinib
  • HY-164326
    KAL-21404358 1065573-84-3
    KAL-21404358 is a ligand for target protein for pROTAC.
    KAL-21404358
  • HY-174874
    POI-4
    POI-4 is a ligand for METTL3. POI-4 can be used for synthesizing PROTACs such as AF151 (HY-174873).
    POI-4
  • HY-168237
    SMARCA2 ligand-10 3024271-84-6
    SMARCA2 ligand-10 is a ligand for a target protein, used for the synthesis of PROTAC SMARCA2 degrader-28(HY-168236).
    SMARCA2 ligand-10
  • HY-167701
    OBHSA 1404508-27-5
    OBHSA is a selective estrogen receptor (ERα) degrader. OBHSA blocks the cell cycle by degrading cyclin D1, thereby overcoming Tamoxifen (HY-13757A) resistance. OBHSA also triggers excessive activation of the unfolded protein response (UPR) by inducing an increase in intracellular reactive oxygen species, ultimately leading to cell apoptosis. In addition, OBHSA can also be used as an ERα ligand to synthesize PROTAC degraders.
    OBHSA
  • HY-W599025
    5-Br-4-Cl-Pyrrolo-pyroxypyridine 2914920-46-8
    5-Br-4-Cl-Pyrrolo-pyroxypyridine is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). 5-Br-4-Cl-Pyrrolo-pyroxypyridine can be used for synthesis PROTAC GSPT1 degrader-1 (HY-159609).
    5-Br-4-Cl-Pyrrolo-pyroxypyridine
  • HY-169482
    ALK protein ligand-1 2764870-80-4
    ALK protein ligand-1 (Compound A1), a ligand for the anaplastic lymphoma kinase (ALK) protein, is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) that exhibits inhibitory effects on ALK. ALK protein ligand-1 can be used in the synthesis of AP-1 (HY-169481).
    ALK protein ligand-1